ATAT1 Antibody (PACO57200)
- SKU:
- PACO57200
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
ATAT1 Antibody (PACO57200)
The ATAT1 Polyclonal Antibody (PACO57200) is a valuable tool for researchers studying ATAT1, an alpha-tubulin N-acetyltransferase enzyme. This antibody, developed for specificity and sensitivity, is raised in rabbits and is optimized for detection of ATAT1 in human samples. Validated for use in Western blot applications, the ATAT1 Polyclonal Antibody binds specifically to the ATAT1 protein, enabling accurate detection and analysis in a variety of cell types.ATAT1 is a critical enzyme involved in the acetylation of alpha-tubulin, a process that plays a key role in microtubule dynamics and cell division.
Dysregulation of ATAT1 has been implicated in various diseases, making it a promising target for research in cancer and neurodegenerative disorders. By studying the function and regulation of ATAT1, researchers can gain valuable insights into cellular processes and potentially develop novel therapeutic strategies targeting this enzyme.
| Antibody Name: | ATAT1 Antibody (PACO57200) |
| Antibody SKU: | PACO57200 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Alpha-tubulin N-acetyltransferase 1 protein (194-238AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO57200 diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO57200 diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO57200 diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. |
| Synonyms: | Alpha-tubulin N-acetyltransferase 1 (Alpha-TAT) (Alpha-TAT1) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog), ATAT1, C6orf134 MEC17 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q5SQI0 |
| NCBI GenInfo Identifier: | 72534730 |
| NCBI Gene ID: | 79969 |
| NCBI Accession: | NP_001026892.1 |
| UniProt Secondary Accession: | Q5SQI0,Q3LIB0, Q5JP39, Q5JP40, Q5JP42, Q5SQI1, Q5SU03 Q86X42, Q8NDK9, Q9BRS1 |
| UniProt Related Accession: | Q5SQI0 |
| Molecular Weight: | |
| NCBI Full Name: | alpha-tubulin N-acetyltransferase 1 isoform 1 |
| NCBI Synonym Full Names: | alpha tubulin acetyltransferase 1 |
| NCBI Official Symbol: | ATAT1Â Â |
| NCBI Official Synonym Symbols: | TAT; MEC17; C6orf134; Nbla00487Â Â |
| NCBI Protein Information: | alpha-tubulin N-acetyltransferase 1; alpha-TAT; alpha-TAT1; acetyltransferase mec-17 homolog |
| UniProt Protein Name: | Alpha-tubulin N-acetyltransferase 1 |
| UniProt Synonym Protein Names: | Acetyltransferase mec-17 homolog |
| Protein Family: | |
| UniProt Gene Name: | ATAT1Â Â |
| UniProt Entry Name: | ATAT_HUMAN |
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