The ATAD5 Antibody (PAC019328) is a reliable tool for researchers investigating the ATAD5 protein, a critical component involved in DNA repair mechanisms. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for Western blot applications. By specifically binding to the ATAD5 protein, researchers can easily detect and analyze its expression in various cell types, making it an essential tool for studies in molecular biology and cancer research.ATAD5 is known to function as a crucial regulator in DNA replication and repair processes, making it a key player in maintaining genomic stability and preventing mutations that can lead to cancer development.
As such, research on ATAD5 can provide valuable insights into cancer biology and potential therapeutic targets for cancer treatment. By understanding the role of ATAD5 in DNA repair mechanisms, researchers can potentially develop new strategies for targeting cancer cells and improving cancer treatments.
Antibody Name:
ATAD5 Antibody (PACO19328)
Antibody SKU:
PACO19328
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ATAD5
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A431 cells, Primary antibody: PACO19328(ATAD5 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
Background:
ATAD5 (ATPase family, AAA domain containing 5), also known as chromosome fragility-associated gene 1 protein, FRAG1 or ELG1, is a 1,844 amino acid, nuclear protein that is involved in the DNA damage response and belongs to the AAA ATPase family. Existing as two alternatively spliced isoforms, ATAD5 interacts with Rad9 in growing cells where it assists in interactions between Rad9 and Bcl-2.
Synonyms:
ATPase family, AAA domain containing 5
UniProt Protein Function:
ATAD5: Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis. Belongs to the AAA ATPase family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 17q11.2Cellular Component: nucleusMolecular Function: ATP bindingBiological Process: response to DNA damage stimulus
