The ATAD3A Polyclonal Antibody (CAB8230) is a valuable tool for research involving ATAD3A, a mitochondrial membrane protein that plays a crucial role in mitochondrial biogenesis and function. This polyclonal antibody, generated in rabbits, offers high specificity and sensitivity for detecting ATAD3A in human samples, making it suitable for various applications including Western blotting.ATAD3A is known for its involvement in mitochondrial nucleoid organization and homeostasis, as well as its interactions with other mitochondrial proteins. Dysfunction of ATAD3A has been linked to mitochondrial disorders and metabolic diseases, highlighting the importance of studying this protein in the context of human health and disease.
Researchers in the fields of cell biology, biochemistry, and molecular biology can benefit from using the ATAD3A Polyclonal Antibody to investigate the mechanisms underlying mitochondrial dynamics and function. By elucidating the role of ATAD3A in cellular metabolism and energy production, this antibody can contribute to a better understanding of mitochondrial dysfunction and its implications for various pathological conditions.
Product Name:
ATAD3A Rabbit Polyclonal Antibody
SKU:
CAB8230
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ATAD3A (NP_001164006.1).
This gene encodes a ubiquitously expressed mitochondrial membrane protein that contributes to mitochondrial dynamics, nucleoid organization, protein translation, cell growth, and cholesterol metabolism. This gene is a member of the ATPase family AAA-domain containing 3 gene family which, in humans, includes two other paralogs. Naturally occurring mutations in this gene are associated with distinct neurological syndromes including Harel-Yoon syndrome. High-level expression of this gene is associated with poor survival in breast cancer patients. A homozygous knockout of the orthologous gene in mice results in embryonic lethality at day 7.5 due to growth retardation and defective development of the trophoblast lineage. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
55210
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse kidney, using ATAD3A Rabbit pAb (CAB8230) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
