The ASPSCR1 Polyclonal Antibody (CAB7481) is specifically designed for research involving ASPSCR1, a gene implicated in the development of alveolar soft part sarcoma. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.ASPSCR1, also known as TFE3 Fusion Partner, is a fusion gene that plays a critical role in the pathogenesis of alveolar soft part sarcoma, a rare soft tissue tumor. Understanding the function and expression of ASPSCR1 is crucial for unraveling the mechanisms underlying this disease and developing targeted therapies.
This polyclonal antibody binds specifically to ASPSCR1, enabling precise detection and analysis in different cell types and tissues. Its high sensitivity and specificity make it an invaluable tool for researchers working in the fields of oncology, molecular biology, and pathology. By studying ASPSCR1 expression and activity, researchers can gain valuable insights into the molecular mechanisms driving alveolar soft part sarcoma and potentially identify new therapeutic targets for this aggressive cancer.
Product Name:
ASPSCR1 Rabbit Polyclonal Antibody
SKU:
CAB7481
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 284-553 of human TUG/ASPSCR1 (NP_076988.1).
The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found.
Purification Method:
Affinity purification
Gene ID:
79058
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using TUG/ASPSCR1 Rabbit pAb (CAB7481) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
