The Asporin Polyclonal Antibody (CAB10311) is a valuable tool for researchers studying the protein Asporin, known for its role in regulating the extracellular matrix in tissues such as bone and cartilage. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Asporin is a key player in processes related to tissue development, regeneration, and repair, making it a promising target for studies in the fields of biomedicine and regenerative medicine. By binding specifically to the Asporin protein, this antibody enables precise detection and analysis of Asporin in various cell types, providing researchers with critical insights into the function and mechanisms of this important protein.
The involvement of Asporin in various diseases and conditions, including osteoarthritis and cancer, underscores its potential as a therapeutic target. Research utilizing the Asporin Polyclonal Antibody can contribute to a deeper understanding of the role of Asporin in these diseases, potentially leading to the development of novel treatment strategies aimed at modulating Asporin's activity for therapeutic benefit.
Product Name:
ASPN Rabbit Polyclonal Antibody
SKU:
CAB10311
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-379 of human ASPN (NP_060150.4).
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
54829
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ASPN Rabbit pAb (CAB10311) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
