ASPH Rabbit Polyclonal Antibody (CAB13153)
- SKU:
- CAB13153
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | ASPH Rabbit Polyclonal Antibody |
SKU: | CAB13153 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 111-270 of human ASPH (NP_001158227.1). |
Sequence: | ERST SEPA VPPE EAEP HTEP EEQV PVEA EPQN IEDE AKEQ IQSL LHEM VHAE HETE HSYH VEET VSQD CNQD MEEM MSEQ ENPD SSEP VVED ERLH HDTD DVTY QVYE EQAV YEPL ENEG IEIT EVTA PPED NPVE DSQV IVEE VSIF PVEE QQEV PPDT |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | AAH; BAH; HAAH; JCTN; FDLAB; junctin; CASQ2BP1; ASPH |
Positive Sample: | A-549,HT-29 |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Sarcoplasmic reticulum membrane, Single-pass type II membrane protein. |
Calculated MW: | 86kDa |
Observed MW: | 86kDa |
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.
Purification Method: | Affinity purification |
Gene ID: | 444 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |