The Aspartoacylase Polyclonal Antibody (CAB7271) is a valuable tool for researchers studying aspartoacylase, a key enzyme involved in the metabolism of N-acetylaspartate (NAA) in the central nervous system. This polyclonal antibody, produced in rabbits, demonstrates high reactivity with human samples and is suitable for use in Western blot applications.Aspartoacylase plays a crucial role in maintaining the balance of NAA levels in the brain, which is important for normal brain function. Dysregulation of aspartoacylase activity has been implicated in various neurological disorders, making it a promising target for research in the fields of neuroscience and neurology.
By specifically binding to the aspartoacylase protein, this antibody enables researchers to detect and analyze its expression in different cell types and tissues. Understanding the role of aspartoacylase in health and disease can provide insights into potential therapeutic strategies for conditions related to NAA metabolism, such as Canavan disease.Overall, the Aspartoacylase Polyclonal Antibody is a valuable tool for investigating the function of this important enzyme and its implications in neurological health. It is a crucial asset in advancing our knowledge of NAA metabolism and its contribution to brain physiology and pathology.
Product Name:
ASPA Rabbit Polyclonal Antibody
SKU:
CAB7271
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human ASPA (NP_001121557.1).
This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
443
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ASPA Antibody (CAB7271) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
