The ASMT Polyclonal Antibody (CAB6529) is a specialized antibody designed for research involving ASMT, an enzyme involved in the metabolism of melatonin. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the ASMT protein, this antibody enables the detection and analysis of ASMT in different cell types, making it an essential tool for studies in the fields of circadian rhythm regulation, sleep disorders, and neurology.ASMT, also known as acetylserotonin O-methyltransferase, plays a crucial role in the biosynthesis of melatonin, a hormone that regulates sleep-wake cycles and other physiological processes.
Abnormalities in ASMT function have been linked to sleep disorders, mood disorders, and various neurological conditions. By studying the activity and regulation of ASMT, researchers can gain valuable insights into the mechanisms underlying these disorders and potentially identify new therapeutic targets for treatment.Overall, the ASMT Polyclonal Antibody (CAB6529) offers researchers a reliable tool for investigating the role of ASMT in melatonin metabolism and its implications for various health conditions. Its high specificity and sensitivity make it a valuable asset for studies aimed at understanding the intricate relationship between circadian rhythms, sleep quality, and overall health.
Product Name:
ASMT Polyclonal Antibody
SKU:
CAB6529
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-298 of human ASMT (NP_001164510.1).
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
438
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using ASMT Rabbit pAb (CAB6529) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
