The ASMT Polyclonal Antibody (CAB16349) is a valuable tool for researchers studying ASMT, a key enzyme involved in melatonin biosynthesis. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in applications such as Western blotting. By binding to the ASMT protein, this antibody allows for accurate detection and analysis in various cell types, making it ideal for studies in neurobiology, sleep disorders, and circadian rhythm regulation.ASMT is an essential enzyme in the conversion of serotonin to melatonin, playing a crucial role in regulating the body's sleep-wake cycle and overall circadian rhythm.
Dysregulation of ASMT activity has been linked to various sleep disorders, mood disorders, and neurodegenerative diseases. By studying ASMT expression and activity using this polyclonal antibody, researchers can gain a better understanding of the mechanisms underlying these conditions and potentially develop new therapeutic interventions.
Product Name:
ASMT Rabbit Polyclonal Antibody
SKU:
CAB16349
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-298 of human ASMT (NP_001164510.1).
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
438
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat heart using ASMT Rabbit pAb (CAB16349) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
