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Anti-ASMT Antibody (CAB16349)

SKU:
CAB16349
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
  • Metabolism Antibodies 2 Anti-ASMT Antibody CAB16349
  • Metabolism Antibodies 2 Anti-ASMT Antibody CAB16349
€139 - €419
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Description

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Antibody Name:Anti-ASMT Antibody
Antibody SKU:CAB16349
Antibody Size:20uL, 50uL, 100uL
Application:IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-298 of human ASMT (NP_001164510.1).
Application:IHC
Recommended Dilution:IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-298 of human ASMT (NP_001164510.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGSS EDQA YRLL NDYA NGFM VSQV LFAA CELG VFDL LAEA PGPL DVAA VAAG VRAS AHGT ELLL DICV SLKL LKVE TRGG KAFY RNTE LSSD YLTT VSPT SQCS MLKY MGRT SYRC WGHL ADAV REGR NQYL ETFG VPAE ELFT AIYR SEGE RLQF MQAL QEVW SVNG RSVL TAFD LSVF PLMC DLGG DFFK DPLP EADL YILA RVLH DWAD GKCS HLLE RIYH TCKP GGGI LVIE SLLD EDRR GPLL TQLY SLNM LVQT EGQE RTPT HYHM LLSS AGFR DFQF KKTG AIYD AILA RK
Gene ID:438
Uniprot:P46597
Cellular Location:
Calculated MW:33kDa/38kDa/41kDa
Observed MW:
Synonyms:ASMT, ASMTY, HIOMT, HIOMTY
Background:This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene.
UniProt Protein Function:ASMT: Produces melatonin (N-acetyl-5-methoxytryptamine) from N-acetylserotonin. Belongs to the methyltransferase superfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - tryptophan; EC 2.1.1.4; Methyltransferase

Chromosomal Location of Human Ortholog: Xp22.33 and Yp11.2

Cellular Component: cytosol

Molecular Function:acetylserotonin O-methyltransferase activity; identical protein binding; O-methyltransferase activity; protein homodimerization activity; S-methyltransferase activity

Biological Process: indolalkylamine biosynthetic process; melatonin biosynthetic process; translation

NCBI Summary:This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]
UniProt Code:P46597
NCBI GenInfo Identifier:1170276
NCBI Gene ID:438
NCBI Accession:P46597.1
UniProt Secondary Accession:P46597,Q16598, Q5JQ72, Q5JQ73, B2RC33,
UniProt Related Accession:P46597
Molecular Weight:Calculated MW: 33kDa/38kDa/41kDaObserved MW: 52kDa
NCBI Full Name:Acetylserotonin O-methyltransferase
NCBI Synonym Full Names:acetylserotonin O-methyltransferase
NCBI Official Symbol:ASMT  
NCBI Official Synonym Symbols:ASMTY; HIOMT; HIOMTY  
NCBI Protein Information:acetylserotonin O-methyltransferase
UniProt Protein Name:Acetylserotonin O-methyltransferase
UniProt Synonym Protein Names:Hydroxyindole O-methyltransferase; HIOMT
Protein Family:Acetylserotonin O-methyltransferase
UniProt Gene Name:ASMT  
Anti-ASMT Antibody (CAB16349)Immunohistochemistry of paraffin-embedded rat heart using ASMT antibody (CAB16349) at dilution of 1:100 (40x lens).
Anti-ASMT Antibody (CAB16349)Immunohistochemistry of paraffin-embedded mouse heart using ASMT antibody (CAB16349) at dilution of 1:100 (40x lens).

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