The ASIP Polyclonal Antibody (CAB6872) is a powerful tool for researchers studying ASIP, a protein involved in regulating pigmentation and melanoma development. This antibody, produced in rabbits, has high specificity for human samples and is validated for use in various applications, including immunohistochemistry and ELISA.ASIP, also known as agouti signaling protein, plays a critical role in controlling the production of melanin in the skin, hair, and eyes. Dysregulation of ASIP has been linked to disorders of pigmentation and even melanoma, a deadly form of skin cancer. By targeting ASIP with this antibody, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for treatment.
With its high reactivity and specificity, the ASIP Polyclonal Antibody (CAB6872) is an essential tool for investigating the role of ASIP in both normal physiological processes and disease states. Whether studying pigmentation disorders, melanoma progression, or other related conditions, this antibody offers researchers a reliable means of detecting and analyzing ASIP expression in various experimental settings.
Product Name:
ASIP Rabbit Polyclonal Antibody
SKU:
CAB6872
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-132 of human ASIP (NP_001663.2).
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
Purification Method:
Affinity purification
Gene ID:
434
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Human prostate cancer using ASIP Rabbit pAb (CAB6872) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
