The ASGR2 Polyclonal Antibody (CAB13949) is a high-quality tool for researchers studying ASGR2, a vital protein involved in liver function and glycoprotein metabolism. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blotting applications. By specifically binding to the ASGR2 protein, this antibody enables accurate detection and analysis in various experimental settings, making it an excellent choice for studies in liver biology, metabolism, and related fields.
ASGR2, also known as the asialoglycoprotein receptor 2, plays a crucial role in the clearance of circulating glycoproteins by liver hepatocytes. Its importance in maintaining proper glycoprotein homeostasis highlights its relevance in understanding liver function, metabolic disorders, and diseases related to glycoprotein metabolism. By investigating the expression and function of ASGR2, researchers can gain insights into liver health, disease mechanisms, and potential therapeutic targets for liver-related conditions.
Product Name:
ASGR2 Rabbit Polyclonal Antibody
SKU:
CAB13949
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 131-287 of human ASGR2 (NP_550435.1).
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
433
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ASGR2 Rabbit pAb (CAB13949) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
