The ASGR1 Polyclonal Antibody (CAB6871) is specifically designed for researchers studying the ASGR1 protein, which plays a key role in binding and internalizing ligands in the liver. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding to the ASGR1 protein, researchers can detect and analyze its presence in various cell types, making it ideal for studies in liver biology, metabolism, and related diseases.
ASGR1, also known as the asialoglycoprotein receptor 1, is involved in the clearance of circulating glycoproteins and plays a crucial role in maintaining liver function. Dysregulation of ASGR1 has been linked to metabolic disorders and liver diseases, making it a potential target for therapeutic interventions. Understanding the function and regulation of ASGR1 is essential for developing treatments for conditions such as fatty liver disease, diabetes, and other metabolic disorders.
Product Name:
ASGR1 Rabbit Polyclonal Antibody
SKU:
CAB6871
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human ASGR1 (NP_001662.1).
Membrane, Secreted, Single-pass type II membrane protein.
Calculated MW:
33kDa
Observed MW:
33kDa/45kDa
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
432
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using ASGR1 Rabbit pAb (CAB6871) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
