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ASGR1 Rabbit Polyclonal Antibody (CAB6871)

SKU:
CAB6871
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 10 Anti-ASGR1 Antibody CAB6871
  • Cell Biology Antibodies 10 Anti-ASGR1 Antibody CAB6871
  • Cell Biology Antibodies 10 Anti-ASGR1 Antibody CAB6871
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:ASGR1 Rabbit Polyclonal Antibody
SKU:CAB6871
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human ASGR1 (NP_001662.1).
Sequence:MTKE YQDL QHLD NEES DHHQ LRKG PPPP QPLL QRLC SGPR LLLL SLGL SLLL LVVV CVIG SQNS QLQE ELRG LRET FSNF TAST EAQV KGLS TQGG NVGR KMKS LESQ LEKQ QKDL SEDH SSLL LHVK QFVS DLRS LSCQ MAAL QGNG SE
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:100 - 1:500 IHC-P,1:50 - 1:200
Synonyms:HL-1; ASGPR; ASGPR1; CLEC4H1; ASGR1
Positive Sample:HepG2,THP-1(Negative control),Mouse liver,Rat liver
Conjugate:Unconjugated
Cellular Localization:Membrane, Secreted, Single-pass type II membrane protein.
Calculated MW:33kDa
Observed MW:33kDa/45kDa

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Purification Method:Affinity purification
Gene ID:432
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using ASGR1 Rabbit pAb (CAB6871) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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