The ASGR1 Polyclonal Antibody (CAB13279) is a valuable tool for researchers studying ASGR1, a cell surface receptor involved in the clearance of circulating glycoproteins. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By targeting the ASGR1 protein, researchers can detect and analyze its expression in various cell types, making it a versatile tool for investigations in liver physiology, glycoprotein metabolism, and diseases related to ASGR1 dysfunction.ASGR1, also known as the asialoglycoprotein receptor 1, plays a crucial role in the recognition and internalization of glycoproteins by hepatocytes, contributing to the maintenance of glucose homeostasis and the clearance of harmful substances from the bloodstream.
Dysregulation of ASGR1 function has been linked to liver diseases, metabolic disorders, and certain types of cancer, underscoring the importance of studying its role in health and disease. The ASGR1 Polyclonal Antibody provides researchers with a reliable means to explore ASGR1 function and its implications in various physiological and pathological conditions.
Product Name:
ASGR1 Rabbit Polyclonal Antibody
SKU:
CAB13279
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 62-291 of human ASGR1 (NP_001662.1).
Membrane, Secreted, Single-pass type II membrane protein.
Calculated MW:
33kDa
Observed MW:
45kDa
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
432
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ASGR1 Rabbit pAb (CAB13279) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
