The ASCL2 Polyclonal Antibody (PAC004341) is a valuable tool for researchers studying ASCL2, a transcription factor involved in the regulation of gene expression and cell differentiation. This antibody, produced in rabbits, is highly specific to human samples and is suitable for use in Western blot applications. It binds to the ASCL2 protein, allowing for reliable detection and analysis in various cell types.ASCL2, also known as Achaete-Scute Family BHLH Transcription Factor 2, plays a crucial role in cell fate determination and tissue development. Dysregulation of ASCL2 has been implicated in various diseases, including cancer and neurodevelopmental disorders.
By understanding the function of ASCL2, researchers can gain insight into the mechanisms underlying these conditions and potentially identify new therapeutic targets.Overall, the ASCL2 Polyclonal Antibody is an essential tool for investigating the biological functions of ASCL2 and its role in disease pathogenesis. Its high specificity and sensitivity make it ideal for use in immunology, cancer research, and developmental biology studies.
Antibody Name:
ASCL2 Antibody
Antibody SKU:
PACO04341
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human Mash2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ASCL2; BHLHA45; HASH2; Achaete-scute homolog 2; ASH-2; hASH2; Class A basic helix-loop-helix protein 45; bHLHa45; Mash2
UniProt Protein Function:
ASCL2: a basic helix-loop-helix transcription factor, plays an essential role in the maintenance of adult intestinal stem cellsProtein type: DNA-bindingChromosomal Location of Human Ortholog: 11p15.5Cellular Component: cytoplasm; nucleusBiological Process: negative regulation of transcription from RNA polymerase II promoter; regulation of neurogenesis; response to hypoxia; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008]
