The ASCL1a Antibody (PAC052690) is a vital tool for researchers studying the ASCL1a protein, a key regulator of neurogenesis and neuronal differentiation. This polyclonal antibody, generated through immunization of rabbits, exhibits high specificity and reactivity towards human samples, making it a reliable choice for Western blot analysis.ASCL1a, also known as Achaete-scute homolog 1a, plays a crucial role in the development of the nervous system, particularly in regulating neural progenitor cell differentiation and neuronal lineage commitment. Dysfunction of ASCL1a has been linked to various neurological disorders and neurodevelopmental conditions, highlighting its importance in understanding brain development and function.
By targeting the ASCL1a protein, researchers can investigate its mechanisms of action in neurogenesis, as well as its potential implications in diseases such as brain tumors, neurodegenerative disorders, and psychiatric illnesses. The ASCL1a Antibody offers a valuable tool for exploring the functions and dysregulation of ASCL1a, paving the way for new insights and therapeutic strategies in neuroscience research.
Antibody Name:
ascl1a Antibody (PACO52690)
Antibody SKU:
PACO52690
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Zebrafish
Immunogen:
Recombinant Zebrafish Achaete-scute homolog 1a protein (1-196AA)
Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells.
Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells.
