The ASCL1 Polyclonal Antibody is a valuable tool for research involving ASCL1, a transcription factor that plays a crucial role in the development of neuronal cells. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blotting and immunohistochemistry applications.ASCL1, also known as Achaete-Scute Family BHLH Transcription Factor 1, is a key regulator of neurogenesis and neuronal differentiation. Its expression is essential for the generation of neurons in the central and peripheral nervous systems, making it a promising target for studies in neuroscience and developmental biology.
By using the ASCL1 Polyclonal Antibody, researchers can accurately detect and analyze the presence of ASCL1 protein in various cell types and tissues. This antibody's high specificity and sensitivity ensure reliable results, making it a valuable tool for investigating the role of ASCL1 in neuronal development and potential therapeutic applications in neurodegenerative diseases.
Product Name:
AscL1 Rabbit Polyclonal Antibody
SKU:
CAB10669
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 150-236 of human AscL1 (NP_004307.2).
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.
Purification Method:
Affinity purification
Gene ID:
429
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using AscL1 Rabbit pAb (CAB10669) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
