The ASCC1 Polyclonal Antibody (CAB15832) is a valuable tool for researchers studying ASCC1, a protein involved in DNA repair and maintenance. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it a reliable tool for Western blot applications. By binding to ASCC1, this antibody allows for the precise detection and analysis of the protein in various cell types.ASCC1, also known as Activating Signal Cointegrator 1 Complex Subunit 1, plays a crucial role in maintaining genomic stability and preserving the integrity of DNA. Its function in DNA repair processes makes it a key player in preventing mutations and genomic alterations that can lead to diseases like cancer.
Research on ASCC1 is essential for understanding the molecular mechanisms underlying DNA damage response and developing targeted therapies for cancer treatment.With its specificity and reliability, the ASCC1 Polyclonal Antibody (CAB15832) is an invaluable tool for scientists investigating DNA repair pathways, genomic stability, and the role of ASCC1 in health and disease. Its use in research can contribute to the development of novel therapeutic strategies for cancer and other diseases related to DNA damage and repair.
Product Name:
ASCC1 Rabbit Polyclonal Antibody
SKU:
CAB15832
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ASCC1 (NP_001185727.1).
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
51008
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from rat pancreas, using ASCC1 Rabbit pAb (CAB15832) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
