The ASB6 Polyclonal Antibody (PAC040894) is a valuable tool for researchers studying ASB6, a member of the Ankyrin repeat and SOCS box-containing protein family. This antibody, generated in rabbits, is highly specific for human ASB6 and validated for use in various applications, including Western blot and immunohistochemistry.ASB6 is involved in the regulation of protein turnover and degradation through interactions with the ubiquitin-proteasome system. Its role in protein degradation pathways makes it a key player in cellular homeostasis and signaling cascades.
Research on ASB6 could provide insights into diseases related to protein misfolding and abnormal protein turnover, such as neurodegenerative disorders and cancer.By using the ASB6 Polyclonal Antibody, researchers can effectively detect and analyze ASB6 expression in different cell types and tissues, advancing our understanding of its functions and potential therapeutic implications. This antibody is a valuable tool for studies focused on molecular mechanisms underlying protein degradation and cellular homeostasis.
Antibody Name:
ASB6 Antibody (PACO40894)
Antibody SKU:
PACO40894
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Ankyrin repeat and SOCS box protein 6 protein (1-197AA)
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO40894 at dilution of 1:100.
Background:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Synonyms:
Ankyrin repeat and SOCS box protein 6 (ASB-6), ASB6
UniProt Protein Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]
