The ASB2 Polyclonal Antibody (CAB17923) is specifically designed for research involving ASB2, a protein involved in the ubiquitination pathway and implicated in various cellular processes, including cell cycle regulation and protein degradation. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. It binds to the ASB2 protein, enabling detection and analysis in a variety of cell types, making it an ideal tool for studies in cell biology and cancer research.
ASB2, also known as ankyrin repeat and SOCS box protein 2, is a key player in the regulation of protein turnover and cellular signaling pathways. Its function in targeting specific proteins for degradation and modulation of signaling cascades makes it a valuable target for research into cancer progression, cell proliferation, and other cellular processes. Understanding the role of ASB2 is essential for unraveling its contribution to disease pathogenesis and identifying potential therapeutic targets for intervention.
Product Name:
ASB2 Rabbit Polyclonal Antibody
SKU:
CAB17923
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 448-587 of human ASB2 (NP_057234.2).
This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
51676
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ASB2 Rabbit pAb (CAB17923) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
