The ASB11 Polyclonal Antibody (PACO40026) is a vital tool for researchers studying ASB11, a protein involved in the ubiquitin-proteasome system. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting ASB11 in human samples. Validated for use in Western blot applications, it allows for precise and reliable analysis of ASB11 expression levels in various cell types.ASB11 is a member of the ankyrin repeat and SOCS box protein family, known for its role in targeting specific proteins for degradation via the ubiquitin-proteasome pathway. Its involvement in protein turnover and regulation makes it a key player in cellular homeostasis and signaling pathways.
By studying ASB11, researchers can gain insights into mechanisms underlying protein degradation and potential therapeutic targets for diseases related to protein misfolding or dysfunction.The ASB11 Polyclonal Antibody is a valuable asset for researchers exploring the functions and regulatory mechanisms of ASB11 in cellular processes and disease pathways. Its high reactivity and specificity make it an essential tool for advancing our understanding of the ubiquitin-proteasome system and its implications in various disease states.
Antibody Name:
ASB11 Antibody (PACO40026)
Antibody SKU:
PACO40026
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Ankyrin repeat and SOCS box protein 11 protein (41-315AA)
Immunohistochemistry of paraffin-embedded human liver cancer using PACO40026 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human breast cancer using PACO40026 at dilution of 1:100.
Background:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Synonyms:
Ankyrin repeat and SOCS box protein 11 (ASB-11), ASB11
UniProt Protein Function:
ASB11: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: Xp22.31
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
