The ASB10 Polyclonal Antibody (PAC015830) is a vital tool for researchers studying ASB10, a protein involved in cellular processes and protein degradation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards ASB10 in human samples, making it ideal for Western blot applications. By binding to ASB10, this antibody enables the visualization and investigation of ASB10 expression in various cell types, making it essential for studies in molecular biology and protein research.
ASB10, a member of the Ankyrin repeat and SOCS box protein family, plays a crucial role in targeting specific proteins for degradation via the ubiquitin-proteasome pathway. Dysregulation of ASB10 has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Research on ASB10 can provide insights into the mechanisms of protein degradation and offer new strategies for drug development in treating these conditions.
Antibody Name:
ASB10 Antibody (PACO15830)
Antibody SKU:
PACO15830
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human ASB10
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A431 cells, Primary antibody: PACO15830(ASB10 Antibody) at dilution 1/1650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
Background:
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. The SOCS box serves to couple suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene.
Synonyms:
ankyrin repeat and SOCS box containing 10
UniProt Protein Function:
ASB10: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 7q36.1Cellular Component: cytoplasm; nucleusDisease: Glaucoma 1, Open Angle, F
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. The SOCS box serves to couple suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2008]
