The ARX Polyclonal Antibody (CAB17267) is a high-quality research tool designed for investigating ARX, a transcription factor important for brain development and function. This antibody, raised in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ARX protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in neuroscience and developmental biology.ARX is a crucial factor in neuronal development, playing a significant role in the formation of the brain's cortex and in the regulation of gene expression in neurons. Mutations in the ARX gene have been linked to several neurological disorders, including X-linked lissencephaly and West syndrome.
Research into the function of ARX is vital for understanding the mechanisms underlying these disorders and for developing potential therapeutic interventions.Overall, the ARX Polyclonal Antibody is a valuable tool for scientists interested in exploring the role of ARX in brain development and neurological diseases, providing reliable and accurate results in Western blot applications. Its versatility and specificity make it an essential component of any research project focused on understanding the complex functions of ARX in neuronal development and function.
Product Name:
ARX Rabbit Polyclonal Antibody
SKU:
CAB17267
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human ARX (NP_620689.1).
Sequence:
LLRQ PTPA VEGA VASG ALAD PATA AADR RASS IAAL RLKA KEHA AQLT QLNI LPGT STGK EVC
This gene is a homeobox-containing gene expressed during development. The expressed protein contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This gene is thought to be involved in CNS development. Expansion of a polyalanine tract and other mutations in this gene cause X-linked cognitive disability and epilepsy.
Purification Method:
Affinity purification
Gene ID:
170302
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ARX Rabbit pAb (CAB17267) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
