The Artemin Polyclonal Antibody (CAB7949) is a valuable tool for research involving Artemin, a member of the glial cell line-derived neurotrophic factor (GDNF) family. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the Artemin protein, this antibody enables precise detection and analysis in various cell types, making it ideal for investigations in neurobiology and cancer research.Artemin, a neurotrophic factor closely related to GDNF, is known for its roles in promoting the survival and differentiation of neurons, especially sensory and sympathetic neurons.
Its involvement in nervous system development and function makes it a promising target for studying diseases such as neurodegenerative disorders and certain types of cancer. Research on Artemin is essential for uncovering its mechanisms of action and exploring its potential therapeutic applications in these pathological conditions.
Product Name:
ARTN Rabbit Polyclonal Antibody
SKU:
CAB7949
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 122-220 of human ARTN (NP_476432.2).
This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma.
Purification Method:
Affinity purification
Gene ID:
9048
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of 22Rv1 cells, using ARTN antibody (CAB7949) at 1:500 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 30s.
