The ARSI Antibody (PAC036126) is a valuable tool for researchers studying ARSI, a protein involved in oxidative stress response and metabolism regulation. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ARSI protein, this antibody enables the detection and analysis of ARSI in various cell types, making it well-suited for investigations in the fields of biochemistry and cell biology.ARSI is known for its role in maintaining cellular homeostasis by scavenging harmful reactive oxygen species and regulating metabolic processes.
Dysregulation of ARSI has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Therefore, gaining insights into the function of ARSI is essential for the development of targeted therapies aimed at mitigating oxidative stress-related pathologies.In conclusion, the ARSI Antibody (PAC036126) holds promise for advancing research in the realms of oxidative stress, metabolism, and disease pathogenesis. Its versatility and specificity make it a valuable asset for scientists seeking to unravel the intricate mechanisms governed by the ARSI protein.
Antibody Name:
ARSI Antibody (PACO36126)
Antibody SKU:
PACO36126
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Arylsulfatase I protein (301-569AA)
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO36126 at dilution of 1:100.
Background:
Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts.
Synonyms:
Arylsulfatase I (ASI) (EC 3.1.6.-), ARSI
UniProt Protein Function:
ARSI: Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. Belongs to the sulfatase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; Hydrolase; Secreted; Calcium-binding; EC 3.1.6.-Chromosomal Location of Human Ortholog: 5q32Cellular Component: endoplasmic reticulum lumen; extracellular regionMolecular Function: arylsulfatase activity; metal ion binding; protein bindingBiological Process: cellular protein metabolic process; glycosphingolipid metabolic process; post-translational protein modification; sphingolipid metabolic process
UniProt Protein Details:
NCBI Summary:
Sulfatases (EC 3.1.5.6), such as ARSI, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
