The ARSB Polyclonal Antibody (CAB14231) is a valuable tool for researchers studying ARSB, a crucial enzyme involved in the breakdown of complex carbohydrates within lysosomes. This antibody, generated in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ARSB protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in lysosomal storage disorders, metabolic diseases, and enzyme replacement therapies.ARSB, also known as arylsulfatase B, plays a vital role in maintaining cellular function by catalyzing the hydrolysis of sulfate esters.
Mutations in the ARSB gene can lead to the accumulation of glycosaminoglycans, causing diseases such as mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome). Understanding the function and regulation of ARSB is essential for developing targeted therapies to treat these lysosomal storage disorders and related metabolic conditions. By utilizing the ARSB Polyclonal Antibody (CAB14231), researchers can further explore the biochemistry and pathophysiology of ARSB, paving the way for advancements in personalized medicine and precision therapeutics.
Product Name:
ARSB Rabbit Polyclonal Antibody
SKU:
CAB14231
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 404-533 of human ARSB (NP_000037.2).
Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
411
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from U-87MG cells, using ARSB Rabbit pAb (CAB14231) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
