The ARRB2 Polyclonal Antibody (CAB16764) is a valuable tool for researchers studying ARRB2, a protein involved in cell signaling pathways and G protein-coupled receptor desensitization. This rabbit-derived antibody is highly specific to human samples and has been validated for use in Western blotting applications. By binding to the ARRB2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in areas such as neuroscience, pharmacology, and cell biology.ARRB2, also known as beta-Arrestin 2, is a key player in the regulation of G protein-coupled receptor signaling, controlling processes such as receptor internalization and desensitization. Its role in modulating cellular responses to various extracellular signals highlights its importance in diverse physiological processes.
Research on ARRB2 is crucial for gaining insight into mechanisms underlying diseases like cancer, cardiovascular disorders, and neurological conditions, as well as for developing novel therapeutic strategies targeting G protein-coupled receptor pathways.By utilizing the ARRB2 Polyclonal Antibody (CAB16764), scientists can unravel the complexities of ARRB2 function and its impact on cellular signaling, paving the way for advancements in drug discovery and personalized medicine. Don't miss out on the opportunity to enhance your research with this high-quality antibody designed for precise and reliable detection of ARRB2 in human samples.
Product Name:
ARRB2 Rabbit Polyclonal Antibody
SKU:
CAB16764
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 295-394 of human ARRB2 (NP_945355.1).
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
409
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from NIH/3T3 cells, using ARRB2 Rabbit pAb (CAB16764) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
