The ARRB2 Polyclonal Antibody (CAB1171) is a valuable tool for researchers studying ARRB2, a key protein involved in intracellular signaling pathways. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to ARRB2, researchers can effectively detect and analyze this protein in a variety of cell types, making it suitable for use in studies related to signal transduction and cell signaling.ARRB2, also known as beta-Arrestin-2, plays a crucial role in the regulation of G protein-coupled receptor signaling, internalization, and trafficking.
Its involvement in various cellular processes makes it a promising target for research focused on understanding the mechanisms underlying diseases such as cancer, cardiovascular disorders, and neurological conditions. Investigating the function of ARRB2 is essential for developing targeted therapies that can modulate these signaling pathways for therapeutic benefits.
Product Name:
ARRB2 Rabbit Polyclonal Antibody
SKU:
CAB1171
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ARRB2 (NP_004304.1).
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
409
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using ARRB2 Rabbit pAb (CAB1171) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
