The ARPP21 Polyclonal Antibody (PAC023400) is a vital tool for researchers studying ARPP21, a protein involved in various cellular processes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot assays. By binding to the ARPP21 protein, this antibody allows for the detection and analysis of ARPP21 expression in a variety of cell types, making it an essential asset for investigations in the fields of molecular biology and biochemistry.
ARPP21, also known as cAMP-regulated phosphoprotein, plays a key role in signal transduction pathways that regulate cellular responses to external stimuli. Its involvement in crucial biological processes makes it a promising target for research on diseases such as cancer, neurological disorders, and metabolic syndromes. Understanding the function of ARPP21 is essential for developing targeted therapies aimed at modulating its activity for therapeutic purposes.
Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.
UniProt Protein Details:
NCBI Summary:
This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
