The ARPP19 Monoclonal Antibody (PAC048562) is a valuable tool for researchers studying ARPP19, a protein involved in the regulation of cell division and cellular signaling pathways. This antibody, produced through a monoclonal antibody technique, exhibits high specificity and sensitivity in detecting ARPP19 in human samples, making it a reliable choice for Western blot applications.ARPP19, also known as cAMP-regulated phosphoprotein 19, is a key player in cell cycle progression and modulation of protein phosphorylation. Its dysregulation has been linked to various diseases, including cancer and neurological disorders.
By targeting ARPP19 with this monoclonal antibody, researchers can gain insights into the role of ARPP19 in disease pathogenesis and potentially identify new therapeutic targets for intervention.With its high reactivity and specificity, the ARPP19 Monoclonal Antibody (PAC048562) is a valuable tool for investigations in cell biology, cancer research, and drug development. Researchers can confidently use this antibody to detect and analyze ARPP19 expression in various experimental settings, advancing our understanding of the molecular mechanisms underlying disease processes.
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO48562 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO48562 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.
UniProt Protein Details:
NCBI Summary:
The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]
