The Arpin Antibody (PACO37454) is a valuable tool for researchers studying Arpin, a key regulator of actin cytoskeleton dynamics and cell migration. This polyclonal antibody, raised in rabbits, is highly specific and reacts with human samples, making it ideal for a variety of experimental applications.Arpin is known for its role in controlling actin polymerization and cell movement, making it a crucial player in processes such as cell motility, adhesion, and invasion. Studies have shown that dysregulation of Arpin expression can lead to abnormal cell behaviors and contribute to diseases like cancer and metastasis.
With its high reactivity and specificity, the Arpin Antibody is validated for use in techniques such as Western blotting and immunofluorescence, allowing for accurate detection and analysis of Arpin protein levels in various cell types and experimental conditions. Researchers in the fields of cell biology, cancer research, and developmental biology will find this antibody valuable for unraveling the complex mechanisms governed by Arpin and its implications in disease pathology.
Western blot. All lanes: ARPIN antibody at 0.5µg/ml + HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 25, 44 kDa. Observed band size: 25 kDa.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO37454 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO37454 at dilution of 1:100.
Background:
Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
ARPIN: Belongs to the UPF0552 family.Protein type: Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 15q26.1Cellular Component: lamellipodiumMolecular Function: protein bindingBiological Process: directional locomotion; negative regulation of actin nucleation; negative regulation of cell migration
