BMAL1 Rabbit Polyclonal Antibody (CAB17334)
- SKU:
- CAB17334
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | BMAL1 Rabbit Polyclonal Antibody |
SKU: | CAB17334 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-510 of human BMAL1 (NP_001284648.1). |
Sequence: | DDIG HLAE CHRQ VLQT REKI TTNC YKFK IKDG SFIT LRSR WFSF MNPW TKEV EYIV STNT VVLA NVLE GGDP TFPQ LTAS PHSM DSML PSGE GGPK RTHP TVPG IPGG TRAG AGKI GRMI AEEI MEIH RIR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | TIC; JAP3; MOP3; ARNTL; PASD3; ARNTL1; BMAL1c; bHLHe5; BMAL1 |
Positive Sample: | HeLa,A-431 |
Cellular Localization: | chromatoid body, nucleoplasm, nucleus, PML body |
Calculated MW: | 69kDa |
Observed MW: | 75-80kDa |
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19.
Purification Method: | Affinity purification |
Gene ID: | 406 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |