HIF1β/ARNT Rabbit Polyclonal Antibody (CAB14705)
- SKU:
- CAB14705
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | HIF1β/ARNT Rabbit Polyclonal Antibody |
SKU: | CAB14705 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human HIF1β/ARNT (NP_001659.1). |
Sequence: | MAAT TANP EMTS DVPS LGPA IASG NSGP GIQG GGAI VQRA IKRR PGLD FDDD GEGN SKFL RCDD DQMS NDKE RFAR SDDE QSSA DKER LARE NHSE IERR RRNK MTAY ITEL SDMV PTCS ALAR KPDK LTIL RMAV SHMK SLRG TGNT STDG SYKP SFLT DQEL KHLI LEAA DGFL FIVS CETG RVVY VSDS VTPV LNQP QSEW FGST LYDQ VHPD DVDK LREQ LSTS ENAL TGRI LDLK TGTV KKEG QQSS MRMC MGSR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 |
Synonyms: | HIF1B; TANGO; bHLHe2; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta; HIF1β/ARNT |
Positive Sample: | Rat uterus |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 87kDa |
Observed MW: | 87kDa |
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 405 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |