The ARMET (ARP, MANF) Monoclonal Antibody (CAB21080) is a valuable tool for researchers studying ARMET and MANF proteins, which are involved in cellular stress response and neuroprotection. This monoclonal antibody, generated in mouse, exhibits high specificity and sensitivity for detecting ARMET and MANF in human samples, making it ideal for immunocytochemistry and immunohistochemistry applications.ARMET and MANF are emerging as key players in cellular protection and survival pathways, with implications in neurodegenerative diseases, metabolic disorders, and cancer.
The ARMET (ARP, MANF) Monoclonal Antibody is a reliable reagent for investigating the expression and localization of these proteins in different cell types and tissues, enabling researchers to further understand their roles in health and disease. By targeting ARMET and MANF, researchers may uncover new therapeutic strategies for treating conditions associated with cellular stress and dysfunction.
Product Name:
ARMET/ARP/MANF Monoclonal Antibody
SKU:
CAB21080
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-182 of human MANF (NP_006001.5).
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
Purification Method:
Affinity purification
Gene ID:
7873
Clone Number:
ARC52199
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ARMET/ARP/MANF antibody (CAB21080) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
