The ARL3 Polyclonal Antibody (CAB16348) is an essential tool for researchers studying ARL3, a member of the ADP-ribosylation factor-like protein family known for its role in intracellular vesicle trafficking and ciliary function. Produced in rabbits, this antibody is highly specific to human ARL3 and has been validated for use in Western blotting applications. By binding to the ARL3 protein, researchers can accurately detect and analyze its expression in various cell types, making it an ideal reagent for studies in cell biology and developmental biology.
ARL3 is a key regulator of ciliary signaling pathways and is essential for maintaining cellular homeostasis. Dysregulation of ARL3 has been linked to ciliary dysfunction and the development of ciliopathies, making it a promising target for research into genetic disorders and cilia-related diseases. By studying the function of ARL3, researchers can gain valuable insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic strategies for their treatment.
Product Name:
ARL3 Rabbit Polyclonal Antibody
SKU:
CAB16348
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-182 of human ARL3 (NP_004302.1).
Enables GDP binding activity; GTP binding activity; and microtubule binding activity. Involved in several processes, including cilium assembly; protein localization to cilium; and small GTPase mediated signal transduction. Acts upstream of or within post-Golgi vesicle-mediated transport. Located in several cellular components, including microtubule cytoskeleton; midbody; and photoreceptor connecting cilium. Implicated in Joubert syndrome and retinitis pigmentosa 83.
Purification Method:
Affinity purification
Gene ID:
403
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ARL3 Rabbit pAb (CAB16348) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
