The ARL1 Polyclonal Antibody (CAB15254) is a essential tool for researchers studying ARL1, a small GTPase protein involved in membrane trafficking and organelle dynamics. This antibody is produced in rabbits and has high specificity for ARL1 protein in human samples, providing reliable results in Western blot analysis.ARL1 is known to regulate vesicle transport between the Golgi apparatus and endosomes, playing a critical role in maintaining cellular homeostasis. Dysregulation of ARL1 has been associated with various diseases, including neurodegenerative disorders and metabolic syndromes, making it a promising target for therapeutic interventions.
By using the ARL1 Polyclonal Antibody, researchers can accurately detect and measure ARL1 protein levels in different cell types, aiding in the understanding of its biological functions and potential implications in disease pathology. This antibody is a valuable asset for studies in cell biology, molecular biology, and drug development, providing insights into new strategies for treating ARL1-related disorders.
Product Name:
ARL1 Rabbit Polyclonal Antibody
SKU:
CAB15254
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 62-181 of human ARL1 (NP_001168.1).
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
400
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ARL1 Rabbit pAb (CAB15254) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
