The ARIH2 Polyclonal Antibody (PACO44604) is a valuable tool for researchers studying ARIH2, a protein involved in the ubiquitin-proteasome pathway and regulating protein degradation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the ARIH2 protein, this antibody enables the detection and analysis of ARIH2 in various cell types, making it an ideal choice for studies in cell biology and cancer research.ARIH2 is known to play a crucial role in protein quality control and maintaining cellular homeostasis through its involvement in protein degradation processes.
Dysregulation of ARIH2 has been implicated in various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic intervention. Understanding the function of ARIH2 is essential for developing strategies to modulate protein turnover and potentially treat diseases associated with protein aggregation and accumulation.
Antibody Name:
ARIH2 Antibody (PACO44604)
Antibody SKU:
PACO44604
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human E3 ubiquitin-protein ligase ARIH2 protein (194-493AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry of paraffin-embedded human lung tissue using PACO44604 at dilution of 1:100.
Background:
E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis.
ARIH2: E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys- 63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis. Belongs to the RBR family. Ariadne subfamily.Protein type: Ubiquitin conjugating system; Ubiquitin ligase; Ligase; EC 6.3.2.-Chromosomal Location of Human Ortholog: 3p21Cellular Component: cytoplasm; nucleus; ubiquitin ligase complexMolecular Function: protein binding; ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activityBiological Process: developmental cell growth; multicellular organismal development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]
