The ARIH2 Polyclonal Antibody (PACO07837) is a crucial tool for researchers studying the ARIH2 protein, an E3 ubiquitin-protein ligase involved in protein degradation and cell cycle regulation. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot experiments. By targeting the ARIH2 protein, this antibody facilitates the detection and analysis of ARIH2 in various cell types, making it an essential tool for studies in molecular biology and cancer research.
ARIH2, also known as TRIAD1, is a key player in the ubiquitin-proteasome system, which is responsible for protein turnover and quality control in cells. Dysregulation of ARIH2 has been linked to various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic intervention. Investigating the function of ARIH2 is crucial for understanding its role in disease pathogenesis and developing targeted therapies to modulate its activity.
ARIH2: E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys- 63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis. Belongs to the RBR family. Ariadne subfamily.Protein type: Ubiquitin conjugating system; Ubiquitin ligase; Ligase; EC 6.3.2.-Chromosomal Location of Human Ortholog: 3p21Cellular Component: cytoplasm; nucleus; ubiquitin ligase complexMolecular Function: protein binding; ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activityBiological Process: developmental cell growth; multicellular organismal development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]
