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ARID4B Antibody (PACO00475)

SKU:
PACO00475
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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ARID4B Antibody (PACO00475)

The ARID4B Polyclonal Antibody (PACO00475) is a valuable tool for researchers studying ARID4B, a transcription factor involved in chromatin remodeling and gene regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications. By targeting the ARID4B protein, this antibody enables precise detection and analysis in various cell types, making it a versatile tool for studies in molecular biology and cancer research.ARID4B, also known as AT-rich interactive domain-containing protein 4B, plays a crucial role in gene expression regulation by modulating chromatin structure.

Its involvement in various biological processes, including cell proliferation and differentiation, highlights its significance in cancer development and progression. By studying ARID4B, researchers can gain insights into the mechanisms underlying tumorigenesis and potentially identify new therapeutic targets for cancer treatment.Overall, the ARID4B Polyclonal Antibody (PACO00475) is a valuable resource for researchers looking to explore the complex functions of ARID4B in physiological and pathological conditions. Its high specificity and sensitivity make it a reliable tool for investigating the role of ARID4B in cancer biology and beyond.

Antibody Name:ARID4B Antibody
Antibody SKU:PACO00475
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the Internal region of human BRCAA1.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ARID4B; BRCAA1; RBBP1L1; RBP1L1; SAP180; AT-rich interactive domain-containing protein 4B; ARID domain-containing protein 4B; 180 kDa Sin3-associated polypeptide; Sin3-associated polypeptide p180; Breast cancer-associated antigen BRCAA1; Hi
UniProt Protein Function:ARID4B: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 1q42.3

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function:protein binding

Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; genetic imprinting; transcription, DNA-dependent; negative regulation of gene expression, epigenetic; positive regulation of transcription from RNA polymerase II promoter; gene expression; spermatogenesis; regulation of gene expression, epigenetic

NCBI Summary:This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:Q4LE39
NCBI GenInfo Identifier:143955276
NCBI Gene ID:51742
NCBI Accession:Q4LE39.2
UniProt Secondary Accession:Q4LE39,Q3MHV4, Q5HY99, Q5T2C2, Q5T2C3, Q5T2C4, Q5T2C5 Q5T2C6, Q6P600, Q86UX1, Q86WR4, A1L465,
UniProt Related Accession:Q4LE39
Molecular Weight:91,140 Da
NCBI Full Name:AT-rich interactive domain-containing protein 4B
NCBI Synonym Full Names:AT rich interactive domain 4B (RBP1-like)
NCBI Official Symbol:ARID4B  
NCBI Official Synonym Symbols:BCAA; BRCAA1; RBP1L1; SAP180; RBBP1L1  
NCBI Protein Information:AT-rich interactive domain-containing protein 4B; Rb-binding protein homolog; SIN3A-associated protein 180; sin3-associated polypeptide p180; ARID domain-containing protein 4B; breast cancer-associated antigen 1; 180 kDa Sin3-associated polypeptide; breast carcinoma-associated antigen; breast cancer-associated antigen BRCAA1; retinoblastoma-binding protein 1-like 1; histone deacetylase complex subunit SAP180
UniProt Protein Name:AT-rich interactive domain-containing protein 4B
UniProt Synonym Protein Names:180 kDa Sin3-associated polypeptide; Sin3-associated polypeptide p180; Breast cancer-associated antigen BRCAA1; Histone deacetylase complex subunit SAP180; Retinoblastoma-binding protein 1-like 1
Protein Family:AT-rich interactive domain-containing protein
UniProt Gene Name:ARID4B  
UniProt Entry Name:ARI4B_HUMAN

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