The ARHGEF9 Polyclonal Antibody (CAB7964) is a valuable tool for researchers studying ARHGEF9, a RhoGEF protein involved in cell signaling and cytoskeletal dynamics. This antibody, produced in rabbits, has high specificity and sensitivity for detecting ARHGEF9 in human samples, making it ideal for Western blot applications.ARHGEF9 is a key regulator of Rho GTPases, which play crucial roles in cell migration, adhesion, and proliferation. Dysregulation of ARHGEF9 has been implicated in various diseases, including cancer and neurological disorders.
Therefore, studying the expression and activity of ARHGEF9 is essential for understanding its role in these conditions and developing targeted therapies.With its ability to specifically target ARHGEF9, this polyclonal antibody is a valuable tool for researchers in the fields of cell biology, cancer research, and neuroscience. By enabling precise detection and analysis of ARHGEF9 in different cell types and tissues, this antibody contributes to advancing our understanding of the protein's function and its potential as a therapeutic target.
Product Name:
ARHGEF9 Rabbit Polyclonal Antibody
SKU:
CAB7964
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 307-516 of human ARHGEF9 (NP_056000.1).
The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. This brain-specific protein also acts as an adaptor protein for the recruitment of gephyrin and together these proteins facilitate receceptor recruitement in GABAnergic and glycinergic synapses. Defects in this gene are the cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy, as well as several other types of cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
23229
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ARHGEF9 antibody (CAB7964) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
