The ARHGEF7 Polyclonal Antibody (CAB1108) is a valuable tool for research involving ARHGEF7, a guanine nucleotide exchange factor involved in regulating Rho GTPase signaling pathways. This antibody, produced in rabbits, exhibits high reactivity towards human samples and is validated for use in Western blot applications. By binding specifically to the ARHGEF7 protein, researchers can effectively detect and analyze its expression in a variety of cell types, making it ideal for studies in cell biology and signal transduction mechanisms.ARHGEF7 plays a crucial role in regulating cytoskeletal dynamics and cell migration, making it a key player in processes like cell division and cell motility.
Its involvement in these fundamental cellular processes makes it a promising target for research into various diseases, including cancer and developmental disorders. By understanding the functions of ARHGEF7, researchers can gain insights into potential therapeutic strategies targeting aberrant cell migration and invasion in disease states.In summary, the ARHGEF7 Polyclonal Antibody (CAB1108) serves as a reliable tool for investigating the functions of ARHGEF7 in cellular processes and disease pathogenesis. Its high specificity and reactivity make it an essential component for researchers studying Rho GTPase signaling and its impact on cellular behavior.
Product Name:
ARHGEF7 Rabbit Polyclonal Antibody
SKU:
CAB1108
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ARHGEF7 (NP_001106984.1).
This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
8874
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ARHGEF7 antibody (CAB1108) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
