ARHGEF6 Antibody (PACO61374)
- SKU:
- PACO61374
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
ARHGEF6 Antibody (PACO61374)
The ARHGEF6 Polyclonal Antibody (PAC061374) is a valuable tool for researchers studying ARHGEF6, a protein involved in regulating cell signaling pathways and cytoskeletal dynamics. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting ARHGEF6 in human samples, making it suitable for a variety of research applications such as Western blotting.ARHGEF6, also known as Rho guanine nucleotide exchange factor 6, plays a crucial role in cell migration, adhesion, and invasion processes.
Its dysregulation has been linked to various diseases, including cancer and neurological disorders. By targeting ARHGEF6 with this antibody, researchers can gain insights into the function and regulation of this protein in different cell types, advancing our understanding of its role in disease pathology and potential therapeutic strategies.
| Antibody Name: | ARHGEF6 Antibody (PACO61374) |
| Antibody SKU: | PACO61374 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Rho guanine nucleotide exchange factor 6 protein (108-239AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO61374 diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Synonyms: | Rho guanine nucleotide exchange factor 6, Alpha-Pix, COOL-2, PAK-interacting exchange factor alpha, Rac/Cdc42 guanine nucleotide exchange factor 6, ARHGEF6, COOL2, KIAA0006, PIXA |
| UniProt Protein Function: | ARHGEF6: Acts as a RAC1 guanine nucleotide exchange factor (GEF). Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; Motility/polarity/chemotaxis; GEFs, Rac/RhoChromosomal Location of Human Ortholog: Xq26.3Cellular Component: cytosol; intracellular; lamellipodiumMolecular Function: guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activityBiological Process: lamellipodium biogenesis; positive regulation of apoptosis; regulation of small GTPase mediated signal transductionDisease: Mental Retardation, X-linked 46 |
| UniProt Protein Details: | |
| NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15052 |
| NCBI GenInfo Identifier: | 17371603 |
| NCBI Gene ID: | 9459 |
| NCBI Accession: | Q15052.2 |
| UniProt Secondary Accession: | Q15052,Q15396, Q5JQ66, Q7Z3W1, Q86XH0, A6NMW9, A8K6S7 B1AL37 |
| UniProt Related Accession: | Q15052 |
| Molecular Weight: | 70,791 Da |
| NCBI Full Name: | Rho guanine nucleotide exchange factor 6 |
| NCBI Synonym Full Names: | Rac/Cdc42 guanine nucleotide exchange factor 6 |
| NCBI Official Symbol: | ARHGEF6Â Â |
| NCBI Official Synonym Symbols: | PIXA; COOL2; MRX46; Cool-2; alphaPIX; alpha-PIXÂ Â |
| NCBI Protein Information: | rho guanine nucleotide exchange factor 6 |
| UniProt Protein Name: | Rho guanine nucleotide exchange factor 6 |
| UniProt Synonym Protein Names: | Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6 |
| Protein Family: | Rho guanine nucleotide exchange factor |
| UniProt Gene Name: | ARHGEF6Â Â |
| UniProt Entry Name: | ARHG6_HUMAN |
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