UniProt Protein Function: | ARHGEF6: Acts as a RAC1 guanine nucleotide exchange factor (GEF). Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; Motility/polarity/chemotaxis; GEFs, Rac/RhoChromosomal Location of Human Ortholog: Xq26.3Cellular Component: cytosol; intracellular; lamellipodiumMolecular Function: guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activityBiological Process: lamellipodium biogenesis; positive regulation of apoptosis; regulation of small GTPase mediated signal transductionDisease: Mental Retardation, X-linked 46 |
UniProt Protein Details: | |
NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15052 |
NCBI GenInfo Identifier: | 17371603 |
NCBI Gene ID: | 9459 |
NCBI Accession: | Q15052.2 |
UniProt Secondary Accession: | Q15052,Q15396, Q5JQ66, Q7Z3W1, Q86XH0, A6NMW9, A8K6S7 B1AL37 |
UniProt Related Accession: | Q15052 |
Molecular Weight: | 70,791 Da |
NCBI Full Name: | Rho guanine nucleotide exchange factor 6 |
NCBI Synonym Full Names: | Rac/Cdc42 guanine nucleotide exchange factor 6 |
NCBI Official Symbol: | ARHGEF6Â Â |
NCBI Official Synonym Symbols: | PIXA; COOL2; MRX46; Cool-2; alphaPIX; alpha-PIXÂ Â |
NCBI Protein Information: | rho guanine nucleotide exchange factor 6 |
UniProt Protein Name: | Rho guanine nucleotide exchange factor 6 |
UniProt Synonym Protein Names: | Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6 |
Protein Family: | Rho guanine nucleotide exchange factor |
UniProt Gene Name: | ARHGEF6Â Â |
UniProt Entry Name: | ARHG6_HUMAN |