ARHGEF6 Antibody (PACO19131)
- SKU:
- PACO19131
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
ARHGEF6 Antibody (PACO19131)
The ARHGEF6 Polyclonal Antibody (PAC019131) is a powerful tool for researchers studying ARHGEF6, a key regulator of cellular processes such as cell migration and proliferation. This antibody, produced in rabbits, demonstrates high specificity and reactivity with human samples, making it a reliable choice for Western blot applications. By binding to the ARHGEF6 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for studies in cell biology and cancer research.ARHGEF6, also known as Rho guanine nucleotide exchange factor 6, plays a crucial role in cell signaling pathways that govern cell movement and growth.
Dysregulation of ARHGEF6 has been linked to diseases such as cancer, where abnormal cell proliferation and migration contribute to tumor development and spread. By studying the function of ARHGEF6, researchers can gain valuable insights into the mechanisms underlying these diseases, potentially leading to the development of novel therapeutic approaches targeting ARHGEF6 activity.
| Antibody Name: | ARHGEF6 Antibody (PACO19131) |
| Antibody SKU: | PACO19131 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human ARHGEF6 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO19131(ARHGEF6 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. |
| Synonyms: | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 |
| UniProt Protein Function: | ARHGEF6: Acts as a RAC1 guanine nucleotide exchange factor (GEF). Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; Motility/polarity/chemotaxis; GEFs, Rac/RhoChromosomal Location of Human Ortholog: Xq26.3Cellular Component: cytosol; intracellular; lamellipodiumMolecular Function: guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activityBiological Process: lamellipodium biogenesis; positive regulation of apoptosis; regulation of small GTPase mediated signal transductionDisease: Mental Retardation, X-linked 46 |
| UniProt Protein Details: | |
| NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15052 |
| NCBI GenInfo Identifier: | 17371603 |
| NCBI Gene ID: | 9459 |
| NCBI Accession: | Q15052.2 |
| UniProt Secondary Accession: | Q15052,Q15396, Q5JQ66, Q7Z3W1, Q86XH0, A6NMW9, A8K6S7 B1AL37 |
| UniProt Related Accession: | Q15052 |
| Molecular Weight: | 70,791 Da |
| NCBI Full Name: | Rho guanine nucleotide exchange factor 6 |
| NCBI Synonym Full Names: | Rac/Cdc42 guanine nucleotide exchange factor 6 |
| NCBI Official Symbol: | ARHGEF6Â Â |
| NCBI Official Synonym Symbols: | PIXA; COOL2; MRX46; Cool-2; alphaPIX; alpha-PIXÂ Â |
| NCBI Protein Information: | rho guanine nucleotide exchange factor 6 |
| UniProt Protein Name: | Rho guanine nucleotide exchange factor 6 |
| UniProt Synonym Protein Names: | Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6 |
| Protein Family: | Rho guanine nucleotide exchange factor |
| UniProt Gene Name: | ARHGEF6Â Â |
| UniProt Entry Name: | ARHG6_HUMAN |
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