The ARHGEF5 Polyclonal Antibody (CAB4196) is a valuable tool for researchers studying ARHGEF5, a protein involved in cell signaling pathways that regulate cell migration and invasion. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to ARHGEF5, researchers can accurately detect and analyze its expression in various cell types, making it ideal for studies in cancer research and cell biology.ARHGEF5, also known as Rho guanine nucleotide exchange factor 5, is a key player in the regulation of Rho GTPases, which control cytoskeletal dynamics and cell movement.
Dysregulation of ARHGEF5 has been linked to cancer metastasis and progression, making it a promising target for therapeutic interventions. Investigating the function of ARHGEF5 provides insights into the mechanisms underlying tumor invasion and offers potential avenues for drug development in the field of oncology.Overall, the ARHGEF5 Polyclonal Antibody (CAB4196) is a reliable tool for researchers interested in unraveling the role of ARHGEF5 in cellular processes, with implications for cancer biology and therapeutic strategies targeting metastasis and invasion.
Product Name:
ARHGEF5 Rabbit Polyclonal Antibody
SKU:
CAB4196
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1248-1597 of human ARHGEF5 (NP_005426.2).
Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.
Purification Method:
Affinity purification
Gene ID:
7984
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ARHGEF5 Rabbit pAb (CAB4196) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
