The ARHGEF3 Polyclonal Antibody (CAB8490) is a powerful tool for researchers studying ARHGEF3, a key regulator of cell migration and invasion in cancer. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the ARHGEF3 protein, researchers can easily detect and analyze this important molecule in various cell types, making it an invaluable asset for studies in oncology and metastasis research.ARHGEF3, also known as Rho guanine nucleotide exchange factor 3, plays a crucial role in promoting cancer cell migration and invasion by activating Rho GTPases.
Understanding the function of ARHGEF3 is essential for developing targeted therapies that inhibit cancer metastasis. By targeting ARHGEF3, researchers can potentially disrupt the spread of cancer cells to other parts of the body, offering new hope for patients with advanced cancers.Overall, the ARHGEF3 Polyclonal Antibody (CAB8490) provides researchers with a reliable tool for investigating the role of ARHGEF3 in cancer progression and metastasis. Its specificity and reliability make it a valuable asset for research aimed at developing novel treatments for aggressive forms of cancer.
Product Name:
ARHGEF3 Rabbit Polyclonal Antibody
SKU:
CAB8490
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 287-526 of human ARHGEF3 (NP_062455.1).
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
50650
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ARHGEF3 antibody (CAB8490) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
