ARHGEF3 Rabbit Polyclonal Antibody (CAB8490)
- SKU:
- CAB8490
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | ARHGEF3 Rabbit Polyclonal Antibody |
SKU: | CAB8490 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 287-526 of human ARHGEF3 (NP_062455.1). |
Sequence: | LEEA INII QGIV AEIN TKTG ESEC RYYK ERLL YLEE GQKD SLID SSRV LCCH GELK NNRG VKLH VFLF QEVL VITR AVTH NEQL CYQL YRQP IPVK DLLL EDLQ DGEV RLGG SLRG AFSN NERI KNFF RVSF KNGS QSQT HSLQ ANDT FNKQ QWLN CIRQ AKET VLCA AGQA GVLD SEGS FLNP TTGS RELQ GETK LEQM DQSD SESD CSMD TSEV SLDC ERME QTDS SCGN SRHG ESNV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | GEF3; STA3; XPLN; ARHGEF3 |
Positive Sample: | MCF7,HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 60kDa |
Observed MW: | 60kDa |
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 50650 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |