The ARHGEF26 Polyclonal Antibody (CAB17677) is a valuable tool for researchers studying ARHGEF26, a protein involved in cell signaling pathways. This rabbit-derived antibody is highly specific to human samples and is validated for use in Western blot applications. By binding to the ARHGEF26 protein, this antibody allows for the detection and analysis of ARHGEF26 expression in various cell types.ARHGEF26, also known as Rho guanine nucleotide exchange factor 26, plays a crucial role in cell migration, adhesion, and cytoskeletal organization. Dysregulation of ARHGEF26 has been implicated in various diseases, including cancer and neurological disorders.
Therefore, understanding the function of ARHGEF26 is essential for uncovering its potential role in disease development and progression.Researchers interested in investigating the signaling pathways involving ARHGEF26 or its potential as a therapeutic target in disease contexts will find the ARHGEF26 Polyclonal Antibody to be a valuable asset in their studies. Its high specificity and reactivity make it a reliable tool for elucidating the function of ARHGEF26 in both normal and pathological conditions.
Product Name:
ARHGEF26 Rabbit Polyclonal Antibody
SKU:
CAB17677
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 592-871 of human ARHGEF26 (NP_056410.3).
This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
26084
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ARHGEF26 Rabbit pAb (CAB17677) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
