The ARHGEF16 Polyclonal Antibody (PAC02573) is a valuable tool for researchers studying ARHGEF16, a protein involved in cellular signaling pathways and actin cytoskeleton organization. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for Western blot analysis.ARHGEF16, also known as Rho Guanine Nucleotide Exchange Factor 16, plays a crucial role in regulating Rho GTPases, which are key regulators of the actin cytoskeleton and cell migration. Dysregulation of ARHGEF16 has been implicated in various diseases, including cancer and neurological disorders.
Therefore, studying the expression and function of ARHGEF16 is essential for understanding its role in disease pathogenesis and identifying potential therapeutic targets.With its ability to specifically bind to ARHGEF16, this polyclonal antibody enables researchers to detect and analyze the protein in different cell types and tissues, making it a valuable tool for investigations in cell biology, cancer research, and neurology. By elucidating the molecular mechanisms underlying ARHGEF16 function, this antibody contributes to advancing our understanding of disease pathology and developing targeted therapies.
Antibody Name:
ARHGEF16 Antibody (PACO22573)
Antibody SKU:
PACO22573
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from Internal of human ARHGEF16.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from A549 cells, using ARHGEF16 antibody.
Background:
Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.
ARHGEF16: a Rho guanine exchange factor protein that contains 1 DH, 1 PH and 1 SH3 domain.Protein type: GEFs; Motility/polarity/chemotaxis; GEFs, Rac/RhoChromosomal Location of Human Ortholog: 1p36.3Cellular Component: cytosolMolecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; Rho GTPase binding; receptor tyrosine kinase binding; PDZ domain bindingBiological Process: regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]
