ARHGEF12 Antibody (PACO19923)
- SKU:
- PACO19923
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ARHGEF12 Antibody (PACO19923)
The ARHGEF12 Polyclonal Antibody (PACO19923) is a valuable tool for researchers studying ARHGEF12, a protein involved in cell signaling pathways related to cell migration, adhesion, and cytoskeletal remodeling. This antibody, raised in rabbits, exhibits high specificity and sensitivity for detecting ARHGEF12 in human samples, making it suitable for Western blot applications.ARHGEF12, also known as LARG (leukemia-associated Rho guanine nucleotide exchange factor), is a key regulator of Rho GTPases, which play essential roles in cellular processes such as cell motility and proliferation.
Dysregulation of ARHGEF12 has been implicated in various diseases, including cancer and neurological disorders, highlighting its importance in biomedical research.By targeting ARHGEF12 with this polyclonal antibody, researchers can gain insights into the function and regulation of this protein in different cell types and disease contexts. This antibody is a valuable resource for investigations into the molecular mechanisms underlying ARHGEF12-mediated signaling pathways, offering opportunities for developing novel therapeutic strategies targeting ARHGEF12 in the future.
| Antibody Name: | ARHGEF12 Antibody (PACO19923) |
| Antibody SKU: | PACO19923 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human ARHGEF12 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19923(ARHGEF12 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19923(ARHGEF12 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. |
| Synonyms: | Rho guanine nucleotide exchange factor (GEF) 12 |
| UniProt Protein Function: | ARHGEF12: a widely-expressed guanine nucleotide exchange factor (GEF) for RhoA GTPase. May act as GTPase-activating protein (GAP) for G-alpha 12 and 13. The fusion protein MLL-ARHGEF12 appears to be a disease driver in acute myeloid leukemia. Two isoforms of the human protein are produced by alternative splicing.Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; OncoproteinChromosomal Location of Human Ortholog: 11q23.3Cellular Component: cytoplasm; cytosolMolecular Function: G-protein-coupled receptor binding; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activityBiological Process: G-protein coupled receptor protein signaling pathway; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q9NZN5 |
| NCBI GenInfo Identifier: | 34395525 |
| NCBI Gene ID: | 23365 |
| NCBI Accession: | Q9NZN5.1 |
| UniProt Secondary Accession: | Q9NZN5,O15086, Q6P526 |
| UniProt Related Accession: | Q9NZN5 |
| Molecular Weight: | 173kDa |
| NCBI Full Name: | Rho guanine nucleotide exchange factor 12 |
| NCBI Synonym Full Names: | Rho guanine nucleotide exchange factor 12 |
| NCBI Official Symbol: | ARHGEF12Â Â |
| NCBI Official Synonym Symbols: | LARG; PRO2792Â Â |
| NCBI Protein Information: | rho guanine nucleotide exchange factor 12 |
| UniProt Protein Name: | Rho guanine nucleotide exchange factor 12 |
| UniProt Synonym Protein Names: | Leukemia-associated RhoGEF |
| Protein Family: | Rho guanine nucleotide exchange factor |
| UniProt Gene Name: | ARHGEF12Â Â |
| UniProt Entry Name: |
| Antibodies |
| ARHGEF12 Antibody (PACO02767) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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